Discovering Brain Penetrant Therapeutics Targeting the NLRP3 Inflammasome Aimed to Address Unwanted Inflammatory Processes in Neurodegenerative Diseases

Time: 12:00 pm
day: Day 1 - Track A - Morning


  • In neurodegenerative diseases, the misfolded proteins driving pathology, such as Abeta, Tau, alpha-synuclein and TDP-43, activate the NLRP3 inflammasome
  • Activating microglia and the NLRP3-ASC pathway in the brain drives inflammation, neuronal death and disease progression
  • Our approach is to target the NLRP3-ASC pathway to reduce neuroinflammation while preserving phagocytosis of the misfolded proteins