First-in-Class Allosteric Inhibitor of NEK7 to Block NLRP3 Inflammasome Assembly

Time: 12:00 pm
day: Day 1 - Track B - Morning

Details:

  • Allosteric inhibition of NEK7 stops NLRP3 complexing
  • NLRP3 complexing can be reversed through NEK7 inhibition
  • Further, NEK7 inhibition initiates downstream changes in inflammatory signalling & suppresses pro-inflammatory cytokine propagation

Speakers: