First-in-Class Allosteric Inhibitor of NEK7 to Block NLRP3 Inflammasome Assembly
Time: 12:00 pm
day: Day 1 - Track B - Morning
Details:
- Allosteric inhibition of NEK7 stops NLRP3 complexing
- NLRP3 complexing can be reversed through NEK7 inhibition
- Further, NEK7 inhibition initiates downstream changes in inflammatory signalling & suppresses pro-inflammatory cytokine propagation
