Regulation of Inflammasomes Activity: A Structural Perspective of NLRP1 Inflammasome Regulation by DPP9

Time: 2:30 pm
day: Day 2 - Track A - Afternoon


  • Cryo-EM structure of NLRP1-DPP9 reveals a ternary complex that can sequester NLRP1-CT
  • DPP9 quenches NLRP1-CT and serves as a checkpoint for activation of the NLRP1 inflammasome
  • NLRP1 proteasomal degradation and disruption of ternary complex can activate NLRP1 inflammasome