Understanding Phase Separation as a Driver of RNA Virus-Induced Activation of the NLRP6 Inflammasome

Time: 3:30 pm
day: Day 1 - Track A - Afternoon


  • Learn how NLRP6 is an inflammasome sensor highly expressed in the GI tract and the liver
  • Evaluate how dsRNA and lipoteichoic acid are direct ligands of NLRP6
  • Assess how ligand sensing induces NLRP6 phase separation, which in turn promotes inflammasome formation and signaling in vitro and in vivo