Marie Kosco Vilbois

Marie Kosco Vilbois

Company: AC Immune SA

Job title: Chief Scientific Officer

Seminars:

Discovering Brain Penetrant Therapeutics Targeting the NLRP3 Inflammasome Aimed to Address Unwanted Inflammatory Processes in Neurodegenerative Diseases 12:00 pm

In neurodegenerative diseases, the misfolded proteins driving pathology, such as Abeta, Tau, alpha-synuclein and TDP-43, activate the NLRP3 inflammasome Activating microglia and the NLRP3-ASC pathway in the brain drives inflammation, neuronal death and disease progression Our approach is to target the NLRP3-ASC pathway to reduce neuroinflammation while preserving phagocytosis of the misfolded proteinsRead more

day: Day 1 - Track A - Morning

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