Martha O’Brien

Martha O’Brien

Company: Promega

Job title: Senior Research Scientist


Complementary Target Engagement and Functional Assays to Probe NLRP3 Pathway Antagonism 10:00 am

Three high throughput amenable, cell-based methods to support inflammasome drug discovery NLRP3 inhibitors verified with multiplexed caspase-1 activity assay and IL-1β immunoassay Live-cell NLRP3 BRET target engagement assay used to probe several NLRP3 inhibitors Establish a relationship between the target binding and functional effects of NACHT domain inhibitors in live cellsRead more

day: Day One

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