Overcoming Species-Specific Limitations in Preclinical Models for Human Disease
Time: 9:01 am
day: Pre-Conference Day
day: Pre-Conference Workshop Day
Details:
One of the greatest challenges in developing inflammasome-targeted therapies is the lack of preclinical models that accurately reflect the complexity of human inflammasome biology. Murine models, while widely used, often fail to capture key species-specific differences in the multi-protein complex components such as NLRP1 and CARD8, as well as the differential regulation of caspases and downstream products.
Engage in this dynamic 3-hour workshop and take part in the discussion on:
- Evaluating the limitations of mouse models in reflecting human inflammasome activity and disease progression
- Investigating the impact of cell type, tissue microenvironment, and activation thresholds on human inflammasome responses
- Utilizing iPSC-derived macrophages and microglia to create human-reliant in vitro models of inflammasome activity
- Establishing reproducible, standardized models such as organoids that can accurately predict clinical outcomes for inflammasome therapies
