Gasdermin-Mediated Pyroptosis: From Noncanonical Inflammasome Activation to Tumor Immunity

Time: 12:00 pm
day: Day 2


  • Exploring the functions of noncanonical inflammasome in epithellial cells, in which IL-18 maturation acts as a link between pyroptotic cell death and activation of type I immunity
  • Uncover noncanonical inflammasome-induced GSDMD pore formation in brain endothellial cells as the cause for BBB breakdown in bacteremia and sepsis; highlight the concept that gasdermin pore could open the BBB
  • Discuss antitumor immune responses triggered by gasdermin activation in tumor cells and the role of gasdermin-mediated pyroptosis as an effector mechanism in tumor immunity and lymphocyte cytoxicity