Speakers

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Adam Schwaid
Associate Principal Scientist
Merck & Co., Inc.

Conference Day Two: Chairing Stream A - Understanding the Molecular Mechanisms of the Inflammasome

Ali Jazayeri
Chief Scientific Officer
OMass Therapeutics

Day Two

Friday, November 6 2020

10:00 am | Discovery of Novel Gasdermin Inhibitors

Andrea Kwakowsky
Senior Research Fellow
University of Auckland

Pre-Conference Workshop Leader - Tuesday, November 16

Anil K. Goyal
CEO & Chairperson
IMMvention Therapeutix, Inc.

Day One

Thursday, November 5 2020

9:00 am | SWOT Analysis-Style Panel Discussion - Topics to be Addressed:

Ashley Mansell
Senior Director of Research & Development/Principal Investigator
Bacainn Therapeutics/Hudson Institute of Medical Research

Day 1 - Track B - Morning

11:30 am | BT032: A Novel NLRP1 & NLRP3 Inhibitor to Treat Pulmonary Inflammation

Colin R. Green
Professor/Chief Scientist
University of Auckland/OcuNexus Therapeutics, Inc. & InflammX Therapeutics, Inc.

Day Two

Friday, November 6 2020

9:30 am | Inflammasome Targeting in Ocular & Neurodegenerative Disease

David J. Bearss
CSO & President
Halia Therapeutics, Inc

Day 1 - Track B - Morning

12:00 pm | First-in-Class Allosteric Inhibitor of NEK7 to Block NLRP3 Inflammasome Assembly

Donald F. Weaver
Director
Krembil Research Institute

Day 2 - Track B - Afternoon

2:00 pm | Novel Inflammasome Targets Relevant To Alzheimer’s Disease

Elsa Sanchez- Lopez
Assistant Professor
University of California San Diego, Department of Orthopedic Surgery

Day 1 - Track A - Afternoon

2:00 pm | Mitochondria as a Central Rheostat of NLRP3 Inflammasome Activation

Gennaro Pagano
Expert Medical Director, Group Leader in Early Development
Roche

Hal Hoffman
Professor & Chief, Division of Pediatric Allergy, Immunology, Rheumatology
University of California at San Diego & Rady Children’s Hospital

Day 2 - Track B - Morning

11:30 am | Monogenic Inflammasome-Mediated Diseases

Hao Wu
Professor
Boston Children’s Hospital & Harvard Medical School

Day 1 - Track A - Morning

12:30 pm | Mechanism of Inflammasome Signaling

Humayun Sharif
Instructor
Harvard Medical School

Day 2 - Track A - Afternoon

2:30 pm | Regulation of Inflammasomes Activity: A Structural Perspective of NLRP1 Inflammasome Regulation by DPP9

James D. Thacker
Founder, Head of Discovery & Science
Therimunex Pharmaceuticals, Inc.

Day 2 - Track B - Afternoon

3:00 pm | The NLRP3 Inflammasome is a Therapeutic Target for Precision Medicine in Chronic Inflammatory Diseases: Fibrosis to Cancer

Johannes Grosse
Sr. Director Pharmacology
VIR Biotechnology

Day 2 - Track A - Morning

11:30 am | Inflammasome in Context: Crosstalk with PAMP Receptors via Purinergic Signals

Juan Pablo de Rivero Vaccari
Research Associate Professor of Neurological Surgery & The Miami Project to Cure Paralysis
University of Miami Miller School of Medicine

Day 1 - Track B - Afternoon

2:00 pm | Inflammasome Signaling After Traumatic Brain Injury: Mechanisms & Biomarkers

Karen Cashmere
Chief Commercial Officer
Zyversa Therapeutics, Inc.

Day Two

Friday, November 6 2020

9:00 am | Identifying The Optimal Therapeutic Applications for Your Inflammasome Inhibitor - Avoid InfiniteThink!

Kate Schroder
Head, Inflammasome Lab & Director IMB Centre for Inflammation & Disease Research
The University of Queensland

Day 2 - Track A - Afternoon

3:00 pm | Caspase-1 is a Therapeutic Target for Inflammatory Disease

Liang Shan
Assistant Professor
Washington University in St. Louis

Day 1 - Track A - Afternoon

2:30 pm | Targeting the CARD8 Inflammasome for HIV Treatment & Cure

Marie Kosco Vilbois
Chief Scientific Officer
AC Immune SA

Day 1 - Track A - Morning

12:00 pm | Discovering Brain Penetrant Therapeutics Targeting the NLRP3 Inflammasome Aimed to Address Unwanted Inflammatory Processes in Neurodegenerative Diseases

Martha O’Brien
Senior Research Scientist
Promega

Day One

Thursday, November 5 2020

9:30 am | Complementary Target Engagement and Functional Assays to Probe NLRP3 Pathway Antagonism

Michael Crackower
Chief Scientific Officer
Ventus Therapeutics

Day 2 - Track B - Afternoon

2:30 pm | Identification of Structurally Distinct, Potent & Selective Brain Penetrant and Peripherally Restricted NLRP3 Inhibitors

Pablo Pelegrin
Scientific Deputy Director
Biomedical Research Institute of Murcia University of Murcia

Day 1 - Track B - Afternoon

2:30 pm | Use of NLRP3 Inflammasome Activity as a Disease Biomarker for Patient Stratification & the Design of Clinical Trials Testing NLRP3 Antagonists

Paul Ashton
President & CEO
Inflammasome Therapeutics, Inc.

Day 2 - Track B - Morning

12:30 pm | Retinal Disease & Inflammasome Activation

Day One

Thursday, November 5 2020

9:00 am | SWOT Analysis-Style Panel Discussion - Topics to be Addressed:

Rebecca Coll
Lecturer in Immunobiology & Principal Investigator
Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast

Day 1 - Track A - Morning

11:30 am | Molecular Mechanisms of Inflammasome Regulation

Robert W. Keane
Professor
University of Miami Miller School of Medicine

Day 1 - Track B - Morning

12:30 pm | Systemic Inflammatory Complications Following Traumatic Brain Injury

Rugmani Iyer
Senior Scientist
Merck & Co., Inc.

Day 2 - Track A - Afternoon

2:00 pm | Exploring Inflammasome Activation & Upstream Signalling to Identify Drug Targets

Seung-Yong Seong
Professor, Department of Microbiology & Immunology & Co- CEO
Shaperon Inc.

Day 2 - Track B - Morning

12:00 pm | Randomized Double-Blind, Placebo- Controlled Phase 2 Trial of NuGel, an Inflammasome Inhibitor, for Atopic Dermatitis

Steve Glover
Co-Founder, Chief Executive Officer & Chairman
Zyversa Therapeutics, Inc.

Day One

Thursday, November 5 2020

9:00 am | SWOT Analysis-Style Panel Discussion - Topics to be Addressed:

Sunhwa Kim
Principal Scientist
Merck Research Institute

Day 2 - Track A - Morning

12:30 pm | Investigating Intricacies of Inflammasome Crosstalk with Other Systems

Vishal Singh
Assistant Professor
Pennsylvania State University

Day 2 - Track A - Morning

12:00 pm | Gut Microbiota Metabolic Dysfunction in the Pathogenesis of Inflammatory Bowel Disease: Role of NLR Inflammasomes