Leveraging Biochemical & Structural Analysis to Uncover Pyroptosis Inhibiting Nanobodies to Prevent Gasdermin D Pore Formation

Time: 1:30 pm
day: Day 1


  • Exploring the effectiveness of six GSDMD-targeting nanobodies in inhibiting pore formation, elucidating their binding characteristics, stability, and impact on pyroptosis
  • Revealing the atomic-level interactions between human GSDMD and two nanobodies for detailed insights into their mode of action and epitope recognition 
  • Demonstrating the potential of nanobody-based intervention in preventing GSDMDmediated pore formation, presenting a promising avenue for developing therapeutics to modulate inflammasome-associated inflammation