Leveraging Biochemical & Structural Analysis to Uncover Pyroptosis Inhibiting Nanobodies to Prevent Gasdermin D Pore Formation
Time: 1:30 pm
day: Day 1
Details:
- Exploring the effectiveness of six GSDMD-targeting nanobodies in inhibiting pore formation, elucidating their binding characteristics, stability, and impact on pyroptosis
- Revealing the atomic-level interactions between human GSDMD and two nanobodies for detailed insights into their mode of action and epitope recognition
- Demonstrating the potential of nanobody-based intervention in preventing GSDMDmediated pore formation, presenting a promising avenue for developing therapeutics to modulate inflammasome-associated inflammation
